Role of Autophagy in Endothelial Damage and Blood-Brain Barrier Disruption in Ischemic Strokeopen access
- Authors
- Kim, Kyeong-A; Shin, Donggeun; Kim, Jeong-Hyeon; Shin, Young-Jun; Rajanikant, G. K.; Majid, Arshad; Baek, Seung-Hoon; Bae, Ok-Nam
- Issue Date
- Jun-2018
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- autophagy; blood-brain barrier; disease progression; endothelial cells; endothelial progenitor cells
- Citation
- STROKE, v.49, no.6, pp.1571 - 1579
- Indexed
- SCIE
SCOPUS
- Journal Title
- STROKE
- Volume
- 49
- Number
- 6
- Start Page
- 1571
- End Page
- 1579
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/6190
- DOI
- 10.1161/STROKEAHA.117.017287
- ISSN
- 0039-2499
- Abstract
- The global burden of neurological diseases including stroke has significantly increased, 1 and an urgent need exists to develop new treatment strategies. Impairment of autophagic regulation has been observed in diseases including neurodegenerative diseases and ischemic stroke, suggesting that modulation of autophagy could be a potential therapeutic target. 2 Endothelial cells (ECs) maintain homeostasis by regulating the vascular tone and permeability and endothelial dysfunction is associated with diverse cardiovascular diseases (CVDs). The integrity of the blood-brain barrier (BBB), which shows selective permeability for substances into the brain, is significantly impaired under ischemic stroke. This review focuses on autophagy in endothelial dysfunction in the context of ischemic stroke and potential targets for therapeutic manipulation.
- Files in This Item
-
Go to Link
- Appears in
Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/6190)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.