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Indole Alkaloids from Tropical Sponge Hyrtios sp as Isocitrate Lyase Inhibitors
- Issue Date
- Jun-2018
- Publisher
- Natural Product Communications
- Keywords
- Hyrtios sp.; beta-Carboline alkaloids; Isocitrate lyase
- Citation
- Natural product communications, v.13, no.6, pp.683 - 685
- Indexed
- SCIE
SCOPUS
- Journal Title
- Natural product communications
- Volume
- 13
- Number
- 6
- Start Page
- 683
- End Page
- 685
- ISSN
- 1934-578X
- Abstract
- A new beta-carboline alkaloid, 3,4-dihydrohyrtiosulawesine (8), and fifteen known alkaloids were isolated from the tropical marine sponge Hyrtios sp. Among these known compounds, beta-ketoserotonin (10) has been isolated for the first time from a natural source. The structures of the isolated compounds were determined by spectroscopic analyses and comparison with literature values. Compound 8 displayed potent inhibitory activities against isocitrate lyase (IC50: 92.9 mu M) from Candida albicans.
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Related Researcher
- Won, Ho shik
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY (DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING)