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Age-associated bimodal transcriptional drift reduces intergenic disparities in transcription

Authors
Min, ByungkukPark, MyungsunJeon, KyuheumPark, Jung SunSeo, HyemyungJeong, SangkyunKang, Yong-Kook
Issue Date
Apr-2018
Publisher
IMPACT JOURNALS LLC
Keywords
aging; gene expression; T cells; Huntington' s disease; multiplex PCR; and transcription
Citation
Aging-us, v.10, no.4, pp.789 - 807
Indexed
SCIE
SCOPUS
Journal Title
Aging-us
Volume
10
Number
4
Start Page
789
End Page
807
URI
https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/6374
DOI
10.18632/aging.101428
ISSN
1945-4589
Abstract
This study addressed the question of how well the quantitative transcriptome structure established in early life is maintained and how consistently it appears with increasing age, and if there is age-associated alteration of gene expression (A(3)GE), how much influence the Huntington's disease (HD) genotype exerts on it. We examined 285 exonic sequences of 175 genes using targeted PCR sequencing in skeletal muscle, brain, and splenic CD4+ T cells of wild-type and HD mice. In contrast to the muscle and brain, T cells exhibited large A(3)GE, suggesting a strong contribution to functional decline of the organism. This A(3)GE was markedly intensified in age-matched HD T cells, which exhibited accelerated aging as determined by reduced telomere length. Regression analysis suggested that gene expression levels change at a rate of approximately 3% per month with age. We found a bimodal relationship in A(3)GE in T cells in that weakly expressed genes in young mice were increasingly transcribed in older animals whereas highly expressed genes in the young were decreasingly expressed with age. This bimodal transcriptional drift in the T cell transcriptome data causes the differences in transcription rate between genes to progressively reduce with age.
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