Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
In vitro and in vivo biosafety analysis of resorbable polyglycolic acid-polylactic acid block copolymer composites for spinal fixation
- Authors
- Yoon, Seung Kyun; Yang, Jin HO; Lim, Hyun Tae; Chang, Young Wook; Ayyoob, Muhammad; Yang, Xin; Kim, Young Jun; Ko, Han Seung; Jho, Jae Young; Chung, Dong June
- Issue Date
- Jan-2021
- Publisher
- MDPI AG
- Keywords
- PGA-PLA block copolymerbioresorbablecompositein vivo degradation testMTT assay
- Citation
- Polymers, v.23, no.1, pp.1 - 16
- Indexed
- SCIE
SCOPUS
- Journal Title
- Polymers
- Volume
- 23
- Number
- 1
- Start Page
- 1
- End Page
- 16
- ISSN
- 2073-4360
- Abstract
- Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Ev-ery specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- Files in This Item
- Go to Link
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Chang, Young-Wook
- ERICA 공학대학 (DEPARTMENT OF MATERIALS SCIENCE AND CHEMICAL ENGINEERING)