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Renal-Clearable Hollow Bismuth Subcarbonate Nanotubes for Tumor Targeted Computed Tomography Imaging and Chemoradiotherapy

Authors
Hu, XiSun, JihongLi, FangyuanLi, RuiqingWu, JiaheHe, JieWang, NanLiu, JiananWang, ShuaifeiZhou, FeiSun, XiaolianKim, DokyoonHyeon, TaeghwanLing, Daishun
Issue Date
Feb-2018
Publisher
American Chemical Society
Keywords
Hollow nanotubes; bismuth subcarbonate; tumor-targeting; CT imaging; chemoradiotherapy; renal clearance
Citation
Nano Letters, v.18, no.2, pp.1196 - 1204
Indexed
SCIE
SCOPUS
Journal Title
Nano Letters
Volume
18
Number
2
Start Page
1196
End Page
1204
URI
https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/6819
DOI
10.1021/acs.nanolett.7b04741
ISSN
1530-6984
Abstract
Although metallic nanomaterials with high X-ray attenuation coefficients have been widely used as X-ray computed tomography (CT) contrast agents, their intrinsically poor biodegradability requires them to be cleared from the body to avoid any potential toxicity. On the other hand, extremely small-sized nanomaterials with outstanding renal clearance properties are not much effective for tumor targeting because of their too rapid clearance in vivo. To overcome this dilemma, here we report on the hollow bismuth subcarbonate nanotubes (BNTs) assembled from renal-clearable ultrasmall bismuth subcarbonate nanoclusters for tumor-targeted imaging and chemoradiotherapy. The BNTs could be targeted to tumors with high efficiency and exhibit a high CT contrast effect. Moreover, simultaneous radio- and chemotherapy using drug-loaded BNTs could significantly suppress tumor volumes, highlighting their potential application in CT imaging-guided therapy. Importantly, the elongated nanotubes could be disassembled into isolated small nanoclusters in the acidic tumor microenvironment, accelerating the payload release and kidney excretion. Such body clearable CT contrast agent with high imaging performance and multiple therapeutic functions shall have a substantial potential for biomedical applications.
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ERICA 공학대학 (DEPARTMENT OF BIONANO ENGINEERING)
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