Hyaluronic acid wreathed, trio-stimuli receptive and on-demand triggerable nanoconstruct for anchored combinatorial cancer therapy
- Authors
- Poudel, Kishwor; Banstola, Asmita; Tran, Tuan Hiep; Thapa, Raj Kumar; Gautam, Milan; Ou, Wenquan; Pham, Le Minh; Maharjan, Srijan; Jeong, Jee-Heon; Ku, Sae Kwang; Choi, Han-Gon; Yong, Chul Soon; Kim, Jong Oh
- Issue Date
- Dec-2020
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Hyaluronic acid; Combination therapy; Photothermal agents; Nanosystem; Responsiveness; CD44 receptors
- Citation
- CARBOHYDRATE POLYMERS, v.249, pp.1 - 14
- Indexed
- SCIE
SCOPUS
- Journal Title
- CARBOHYDRATE POLYMERS
- Volume
- 249
- Start Page
- 1
- End Page
- 14
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/708
- DOI
- 10.1016/j.carbpol.2020.116815
- ISSN
- 0144-8617
- Abstract
- Hyaluronic acid (HA) assisted effective internalization into CD44 receptor-overexpressing cancer cells, which could offer an excellent cytotoxic profile and tumor alterations. In this study, duo-photothermal agents (copper sulfide (CuS) and graphene oxide (GO)), chemotherapeutic drug (doxorubicin (DOX)), and targeting moiety (HA) were incorporated into a complexed nanoconstruct for trio-responsive chemo-phototherapy. The nano system (CuS(DOX)-GO-HA) was demonstrating its responsive drug release and escalated photothermal behavior. The hyperthermia and photodynamic effect were observed along with efficient ROS generation in the presence of dual photosensitizers. The in vivo biodistribution and photothermal profile reflected a high accumulation and retention of the nanoconstruct in the tumor. Importantly, nanoconstructs effectively inhibit tumor growth based on tumor volume analysis and the altered expression of apoptosis, cell proliferation, and angiogenesis markers. Collectively, these findings suggest that this nanoconstruct has excellent antitumor effects in CD44 over expressed cells showing the potential for clinical translation in the future.
- Files in This Item
-
Go to Link
- Appears in
Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.