Synthesis of L-Ribose from D-Ribose by a Stereoconversion through Sequential Lactonization as the Key Transformation
- Authors
- Ban, Jaeyoung; Shabbir, Saira; Lim, Minkyung; Lee, Byunghoon; Rhee, Hakjune
- Issue Date
- Sep-2017
- Publisher
- Georg Thieme Verlag
- Keywords
- L-ribose; D-ribose; sugar; lactonization; DIBAL-H; reduction
- Citation
- Synthesis, v.49, no.18, pp.4299 - 4302
- Indexed
- SCIE
SCOPUS
- Journal Title
- Synthesis
- Volume
- 49
- Number
- 18
- Start Page
- 4299
- End Page
- 4302
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/9028
- DOI
- 10.1055/s-0036-1588857
- ISSN
- 0039-7881
- Abstract
- Ribose, a key precursor of various L-nucleosides can only be synthesized from other sugars or other non-sugar precursors. Herein, the study involves the synthesis of naturally rare L-ribose from readily available D-ribose. Though, many synthetic strategies are developed to meet the increasing demands of L-ribose, seeking innovation, a synthesis employing sequential lactonization as the key transformation was explored. This novel conversion involves protection, oxidation, sequential lactonization, reduction with DIBAL-H, and deprotection.
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Collections - COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY > DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING > 1. Journal Articles
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