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Hypoxanthine phosphoribosyltransferase (HPRT)-deficiency is associated with impaired fertility in the female rat
- Authors
- Meek, Stephen; Sutherland, Linda; Wei, Jun; Sturmey, Roger; Binas, Bert; Clinton, Michael; Burdon, Tom
- Issue Date
- Sep-2020
- Publisher
- John Wiley & Sons Inc.
- Citation
- Molecular Reproduction and Development, v.87, no.9, pp 930 - 933
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- Molecular Reproduction and Development
- Volume
- 87
- Number
- 9
- Start Page
- 930
- End Page
- 933
- ISSN
- 1040-452X
1098-2795
- Abstract
- The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites, and here we show that HPRT deficiency in the rat disrupts early embryonic development and causes infertility in females.
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