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Tandem malonate-based glucosides (TMGs) for membrane protein structural studiesopen access

Authors
Hussain, HazratMortensen, Jonas S.Du, YangSantillan, ClaudiaRibeiro, OrquideaGo, JuyeonHariharan, ParameswaranLoland, Claus J.Guan, LanKobilka, Brian K.Byrne, BernadetteChae, Pil Seok
Issue Date
Dec-2017
Publisher
Nature Publishing Group
Citation
Scientific Reports, v.7, no.1, pp.1 - 11
Indexed
SCIE
SCOPUS
Journal Title
Scientific Reports
Volume
7
Number
1
Start Page
1
End Page
11
URI
https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/9517
DOI
10.1038/s41598-017-03809-3
ISSN
2045-2322
Abstract
High-resolution membrane protein structures are essential for understanding the molecular basis of diverse biological events and important in drug development. Detergents are usually used to extract these bio-macromolecules from the membranes and maintain them in a soluble and stable state in aqueous solutions for downstream characterization. However, many eukaryotic membrane proteins solubilized in conventional detergents tend to undergo structural degradation, necessitating the development of new amphiphilic agents with enhanced properties. In this study, we designed and synthesized a novel class of glucoside amphiphiles, designated tandem malonate-based glucosides (TMGs). A few TMG agents proved effective at both stabilizing a range of membrane proteins and extracting proteins from the membrane environment. These favourable characteristics, along with synthetic convenience, indicate that these agents have potential in membrane protein research.
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COLLEGE OF ENGINEERING SCIENCES > DEPARTMENT OF BIONANO ENGINEERING > 1. Journal Articles

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ERICA 공학대학 (DEPARTMENT OF BIONANO ENGINEERING)
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