Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity
- Authors
- Kim, Ki Hyun; Moon, Eunjung; Lee, Seoung Rak; Park, Kyoung Jin; Kim, Sun Yeou; Choi, Sang Un; Lee, Kang Ro
- Issue Date
- Nov-2015
- Publisher
- SOC BRASILEIRA QUIMICA
- Keywords
- Raphanus sativus; Brassicaceae; cytotoxicity; anti-inflammation; Mosher' s method
- Citation
- JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v.26, no.11, pp.2307 - 2312
- Journal Title
- JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
- Volume
- 26
- Number
- 11
- Start Page
- 2307
- End Page
- 2312
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10000
- DOI
- 10.5935/0103-5053.20150222
- ISSN
- 0103-5053
- Abstract
- As part of our ongoing search for bioactive constituents of natural Korean medicinal resources, a bioassay-guided fractionation and chemical investigation of the MeOH extract of Raphanus sativus (Brassicaceae) seeds resulted in the isolation and identification of fifteen compounds, including a new phenolic compound. The structure of the new compound was determined by extensive spectroscopic analysis and the Mosher's method. One of the compounds has been recently reported as a synthetic product. Some compounds showed moderate antiproliferative activities against the tumor cell lines A549, SK-OV-3, SK-MEL-2, and HCT-15 with IC50 values in the range of 5.62 to 28.88 mu M. Moreover, the anti-neuroinflammatory activities of the isolates were determined by measuring the nitric oxide (NO) levels in the medium using murine microglia BV-2 cells. With exception of one specific compound, all the others inhibited the lipopolysaccharide (LPS)-stimulated NO production (IC50 values < 200 mu M).
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