Facile design and spectroscopic characterization of novel bio-inspired Quercetin-conjugated tetrakis (dimethylsulfoxide)dichlororuthenium(II) complex for enhanced anticancer properties
- Authors
- Lakshmi, Buddolla Anantha; Bae, Jin-Young; An, Jeong Ho; Kim, Sanghyo
- Issue Date
- 1-Sep-2019
- Publisher
- ELSEVIER SCIENCE SA
- Keywords
- Ruthenium(II); Quercetin; Metal-based flavonoid; Non-small cell lung cancer cell line; Cytotoxicity; Atomic force microscopy
- Citation
- INORGANICA CHIMICA ACTA, v.495
- Journal Title
- INORGANICA CHIMICA ACTA
- Volume
- 495
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1015
- DOI
- 10.1016/j.ica.2019.118989
- ISSN
- 0020-1693
- Abstract
- A facile reflux approach was employed in the design of novel complexes using ruthenium(II) and quercetin for enhanced anticancer applications. The designed metal-based flavonoid complex was thoroughly characterized by employing powder XRD, H-1, C-13 NMR, elemental analysis (C, H, N, S, O), FT-IR, XPS, and UV-Vis spectroscopy techniques. The cell toxicity and cell proliferation properties of the Quercetin-Ru(II) complex were investigated on the non-small cell lung cancer cell lines (A549) along with the lung normal cells (WI-38) and human dermal fibroblast (HDFa) cells. Significant cytotoxicity was observed with the newly designed complex on A549 cells at minimum concentrations of (10-30 mu M). Interestingly, no remarkable cytotoxicity was observed in the WI-38 and HDFa cells. The same was confirmed by assessing cellular damage and nuclear damage via Atomic force microscopy (Bio-AFM) and Hoechst staining assay. Moreover, the results of intracellular reactive oxygen species (ROS) generation are also interesting to confirm the abilities of designed novel Quercetin-Ru(II) complex for anticancer applications.
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