Subcentimeter hypervascular nodule with typical imaging findings of hepatocellular carcinoma in patients with history of hepatocellular carcinoma: natural course on serial gadoxetic acid-enhanced MRI and diffusion-weighted imaging
- Authors
- Song, Kyoung Doo; Kim, Seong Hyun; Lim, Hyo Keun; Jung, Sin-Ho; Sohn, Insuk; Kim, Hyung Sik
- Issue Date
- Sep-2015
- Publisher
- SPRINGER
- Keywords
- Subcentimeter; Hypervascular nodule; Hepatocellular carcinoma; Natural course; Progression rate
- Citation
- EUROPEAN RADIOLOGY, v.25, no.9, pp.2789 - 2796
- Journal Title
- EUROPEAN RADIOLOGY
- Volume
- 25
- Number
- 9
- Start Page
- 2789
- End Page
- 2796
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10182
- DOI
- 10.1007/s00330-015-3680-9
- ISSN
- 0938-7994
- Abstract
- Objectives To evaluate the natural course of subcentimeter hypervascular nodules at high risk for developing into hepatocellular carcinomas (SHNHR) using serial magnetic resonance imaging (MRI) in patients with a history of hepatocellular carcinoma (HCC). Methods An SHNHR was defined as a subcentimeter hypervascular nodule having typical imaging findings of HCC on gadoxetic acid-enhanced MRI and diffusion-weighted imaging. We included 39 patients with 46 SHNHRs (mean size +/- standard deviation, 6.1 +/- 1.6 mm; range, 3.2 - 9.0 mm). Overt HCC was defined as pathology proven HCC or a nodule larger than 1 cm with typical imaging findings of HCC. The cumulative rate and the independent predictive factors for progression to overt HCC were evaluated. Results The median follow-up period was 139 days (range, 64 - 392 days). The cumulative progression rate to overt HCC at 3, 6, 9, and 12 months was 13.9 %, 61.7 %, 83.2 %, and 89.9 %. The initial size of SHNHR was a significant predictor of progression to overt HCC, with an optimal cut-off value of 5.5 mm. Conclusion The progression rate of SHNHR to overt HCC within 12 months was high (89.9 %) in patients with history of HCC. The initial size of SHNHR was an important predictor for progression to overt HCC.
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