Comparison of inhibitory activity of bioactive molecules on the dextransucrase from Streptococcus mutans
- Authors
- Lee, Choon Geun; Park, Jae Kweon
- Issue Date
- Sep-2015
- Publisher
- SPRINGER
- Keywords
- Dextransucrase; Streptococcus mutans; Antimicrobial activity; Oral health; Chitosan
- Citation
- APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.99, no.18, pp.7495 - 7503
- Journal Title
- APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 99
- Number
- 18
- Start Page
- 7495
- End Page
- 7503
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10203
- DOI
- 10.1007/s00253-015-6693-z
- ISSN
- 0175-7598
- Abstract
- The effect of chitosan with different molecular weights and other natural substances on dextransucrase (DSase) activity from a representative oral pathogen Streptococcus mutans was elucidated. Among other bioactive substances, amino-monosaccharides such as glucosamine, mannosamine, and galactosamine exerted the enzyme inhibitory activity over 95 % of DSase. The specified hydrolysates derived from the hydrolysis of high molecular weight chitosan (HMWC) designated to CTSN, CTSN-P, CTSN-B, and CTSN-S with different molecular weights ranging from 3 to 8 kDa showed the similar inhibitory activity toward DSase. Also, the hyaluronic acid (MW 8.9 kDa), sulfated chitin, and amino-monosaccharides demonstrated the significant activity, CTSN, CTSN-P, CTSN-B, and CTSN-S are of potent bioactive substances that can be prepared in the cheapest way compared with other molecules tested available for antibacterial agent useful for human oral health.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 바이오나노대학 > 생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10203)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.