Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray
- Authors
- Seo, Hye-Sook; Woo, Jong-Kyu; Shin, Yong Cheol; Ko, Seong-Gyu
- Issue Date
- Jul-2015
- Publisher
- SPANDIDOS PUBL LTD
- Keywords
- breast cancer; rexinoid; biomarker; LGD1069; LG100268; Ro25-7386
- Citation
- MOLECULAR MEDICINE REPORTS, v.12, no.1, pp.800 - 818
- Journal Title
- MOLECULAR MEDICINE REPORTS
- Volume
- 12
- Number
- 1
- Start Page
- 800
- End Page
- 818
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10394
- DOI
- 10.3892/mmr.2015.3480
- ISSN
- 1791-2997
- Abstract
- Retinoids possess anti-proliferative properties, which suggests that they possess chemopreventive and therapeutic potential against cancer. In the current study, genes modulated by rexinoids (retinoid X receptor (RXR)-pan agonists, LGD1069 and LG100268; and the RXR agonist, Ro25-7386) were identified using an Affymetrix microarray in normal and malignant breast cells. It was observed that LGD1069, LG100268 and Ro25-7386 suppressed the growth of breast cells. Secondly, several rexinoid-regulated genes were identified, which are involved in cell death, cell growth/maintenance, signal transduction and response to stimulus. These genes may be associated with the growth-suppressive activity of rexinoids. Therefore, the identified genes may serve as biomarkers and novel molecular targets for the prevention and treatment of breast cancer.
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