Lignan Glycosides from the Twigs of Chaenomeles sinensis and Their Biological Activities
- Authors
- Kim, Chung Sub; Subedi, Lalita; Kim, Sun Yeou; Choi, Sang Un; Kim, Ki Hyun; Lee, Kang Ro
- Issue Date
- May-2015
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.78, no.5, pp.1174 - 1178
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 78
- Number
- 5
- Start Page
- 1174
- End Page
- 1178
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10589
- DOI
- 10.1021/acs.jnatprod.5b00090
- ISSN
- 0163-3864
- Abstract
- Phytochemical investigation of the twigs of Chaenomeles sinensis led to the isolation and identification of six new lignan glycosides, chaenomiside A-F (1-6), along with five known ones (7-11). Their chemical structures were determined by spectroscopic methods, including NMR, MS, ECD, and GC/MS analyses. All the isolated compounds (1-11) were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-activated murine microglial cells and the secretion of nerve growth factor (NGF) in a C6 rat glioma cell line. Compound 6 significantly reduced NO levels in the murine microglia BV2 cells with an IC50 value of 21.3 mu M, and compounds 1, 3, and 6 were potent stimulants of NGF release with stimulation levels of 151.74 +/- 6.77%, 144.31 +/- 7.49%, and 167.61 +/- 18.5%, respectively.
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