Lignans from the stems and leaves of Brandisia hancei and their effects on VEGF-induced vascular permeability and migration of HRECs and DLAV formation in zebrafish
- Authors
- Lee, Ik-Soo; Kim, Young Sook; Jung, Seung-Hyun; Yu, Song Yi; Kim, Joo-Hwan; Sun, Hang; Kim, Jin Sook
- Issue Date
- 3-Apr-2015
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- lignans; Scrophulariaceae; vascular endothelial growth factor; zebrafish; Brandisia hancei
- Citation
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.79, no.4, pp.581 - 586
- Journal Title
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Volume
- 79
- Number
- 4
- Start Page
- 581
- End Page
- 586
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10599
- DOI
- 10.1080/09168451.2014.991687
- ISSN
- 0916-8451
- Abstract
- In our continuing search for novel antiangiogenic agents, a new lignan glycoside, (7R,8R)-1-(4-O-beta-d-glucopyranosyl-3-methoxyphenyl)-2-{2-methoxy-4-[1-(E)-propene-3-ol]-phenoxyl}-propane-1,3-diol (1), along with three known lignans (2-4), were isolated from the 80% EtOH extract of Brandisia hancei stems and leaves. These isolates (1-4) were subjected to an in vitro bioassay to evaluate their effects on vascular endothelial growth factor (VEGF)-induced vascular permeability and migration of human retinal endothelial cells (HRECs). Of the compounds tested, compound 1 resulted in the greatest reduction in VEGF-induced vascular permeability by about 31.5% at 10 mu M compared to the VEGF-treated control. In the migration assay, compounds 1 and 2 significantly decreased VEGF-induced HREC migration. Furthermore, zebrafish embryos treated with compounds 1 and 2 showed mild reductions of dorsal longitudinal anastomotic vessel (DLAV) formation.
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