Liposomal co-delivery of curcumin and albumin/paclitaxel nanoparticle for enhanced synergistic antitumor efficacy
- Authors
- Ruttala, Hima Bindu; Ko, Young Tag
- Issue Date
- 1-Apr-2015
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Curcumin; Albumin PTX nanoparticle; Liposome; Synergism; Apoptosis
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v.128, pp.419 - 426
- Journal Title
- COLLOIDS AND SURFACES B-BIOINTERFACES
- Volume
- 128
- Start Page
- 419
- End Page
- 426
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10609
- DOI
- 10.1016/j.colsurfb.2015.02.040
- ISSN
- 0927-7765
- Abstract
- Paclitaxel (PTX) and curcumin (CUR) are potent chemotherapeutic agents used in the treatment of cancer. In the present study, hybrid polymer-lipid nanoparticles co-loaded with PTX and CUR were developed to investigate the therapeutic potential of a combination drug regimen. For this purpose, PTX-loaded albumin nanoparticles (APN) were prepared and encapsulated in PEGylated hybrid liposomes containing CUR (CL-APN) via a thin-film hydration technique. CL-APN was nanosized with a uniform spherical morphology. PTX and CUR release was sustained and occurred in a sequential manner, wherein CUR was expected to downregulate the nuclear factor NF-kappa B and Akt pathways and increase the therapeutic efficacy of PTX. The ratiometric combination of PTX and CUR was significantly more cytotoxic than the individual drugs. Importantly, dual-drug-loaded nanocarriers exhibited a superior cytotoxic effect than a cocktail combination at a lower dose. CL-APN induced significantly higher early and late apoptosis, induced a stronger G(2)/M arrest, and significantly increased the subG(1) cell population. By combining CUR, an effective NF-kappa B inhibitor, with PTX, a powerful anticancer drug, in a polymer-lipid hybrid nanoparticle system, we could improve the therapeutic efficacy in cancer treatments. Our results showed that such co-loaded delivery systems could serve as a promising therapeutic approach to improve clinical outcomes against various malignancies. (C) 2015 Elsevier B.V. All rights reserved.
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