Anti-Obesity Effects of the Flower of Prunus persica in High-Fat Diet-Induced Obese Mice
- Authors
- Song, Jungbin; Kim, Young-Sik; Kim, Linae; Park, Hyo Jin; Lee, Donghun; Kim, Hocheol
- Issue Date
- Sep-2019
- Publisher
- MDPI
- Keywords
- Prunus persica; peach blossom; high-fat diet; anti-obesity; glucose; liver; lipogenesis; beta-oxidation
- Citation
- NUTRIENTS, v.11, no.9
- Journal Title
- NUTRIENTS
- Volume
- 11
- Number
- 9
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1070
- DOI
- 10.3390/nu11092176
- ISSN
- 2072-6643
- Abstract
- Prunus persica (L.) Batsch is a deciduous fruit tree cultivated worldwide. The flower of P. persica (PPF), commonly called the peach blossom, is currently consumed as a tea for weight loss in East Asia; however, its anti-obesity effects have yet to be demonstrated in vitro or in vivo. Since PPF is rich in phytochemicals with anti-obesity properties, we aimed to investigate the effects of PPF on obesity and its underlying mechanism using a diet-induced obesity model. Male C57BL/6 mice were fed either normal diet, high-fat diet (HFD), or HFD containing 0.2% or 0.6% PPF water extract for 8 weeks. PPF significantly reduced body weight, abdominal fat mass, serum glucose, alanine transaminase and aspartate aminotransferase levels, and liver and spleen weights compared to the HFD control group. Real-time quantitative polymerase chain reaction analysis revealed that PPF suppressed lipogenic gene expression, including stearoyl-CoA desaturase-1 and -2 and fatty acid synthase, and up-regulated the fatty acid beta-oxidation gene, carnitine palmitoyltransferase-1, in the liver. Our results suggest that PPF exerts anti-obesity effects in obese mice and these beneficial effects might be mediated through improved hepatic lipid metabolism by reducing lipogenesis and increasing fatty acid oxidation.
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