Protective Effect of Tetrahydrocurcumin against Cisplatin-Induced Renal Damage: In Vitro and In Vivo Studies
- Authors
- Song, Kyung Il; Park, Jun Yeon; Lee, Seungyong; Lee, Dahae; Jang, Hyuk-Jai; Kim, Su-Nam; Ko, Hyeonseok; Kim, Hyun Young; Lee, JaeWook; Hwang, Gwi Seo; Kang, Ki Sung; Yamabe, Noriko
- Issue Date
- Mar-2015
- Publisher
- GEORG THIEME VERLAG KG
- Keywords
- cisplatin; nephrotoxicity; tetrahydrocurcumin; oxidative renal damage; COX-2
- Citation
- PLANTA MEDICA, v.81, no.4, pp.286 - 291
- Journal Title
- PLANTA MEDICA
- Volume
- 81
- Number
- 4
- Start Page
- 286
- End Page
- 291
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10718
- DOI
- 10.1055/s-0035-1545696
- ISSN
- 0032-0943
- Abstract
- The adverse effects of anticancer drugs can prompt patients to end their treatment despite the efficacy. Cisplatin is a platinum-based molecule widely used to treat various forms of cancer, but frequent and long-term use of cisplatin is limited due to severe nephrotoxicity. In the present study, we investigated the protective effect and mechanism of tetrahydrocurcumin on cisplatin-induced kidney damage, oxidative stress, and inflammation to evaluate its possible use in renal damage. Cisplatin-induced LLC-PK1 renal cell damage was significantly reduced by tetrahydrocurcumin treatment. Additionally, the protective effect of tetrahydrocurcumin on cisplatin-induced oxidative renal damage was investigated in rats. Tetrahydrocurcumin was orally administered every day at a dose of 80 mg/kg body weight for ten days, and a single dose of cisplatin was administered intraperitoneally (7.5 mg/kg body weight) in 0.9% saline on day four. The creatinine clearance levels, which were markers of renal dysfunction, in cisplatin-treated rats were recovered nearly back to normal levels after administration of tetrahydrocurcumin. Moreover, tetrahydrocurcumin exhibited protective effects against cisplatin-induced oxidative renal damage in rats by inhibiting cyclooxygenase-2 and caspase-3 activation. These results collectively provide therapeutic evidence that tetrahydrocurcumin ameliorates renal damage by regulating inflammation and apoptosis.
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