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Determination of a novel phosphodiesterase4 inhibitor, 3-[1-(3cyclopropylmethoxy-4-difluoromethoxybenzyl)-1H-pyrazol-3-yl]benzoic acid (PDE-423) in rat plasma using liquid chromatography-tandem mass spectrometry
- Authors
- Cho, Woon-Ki; Seo, Hyewon; Choi, Sung Heum; Kwak, Hyun Jeong; Cheon, Hyae Gyeong; Jeon, Dong Ju; Kim, Sang Kyum; Bae, Myung Ae; Song, Jin Sook
- Issue Date
- Mar-2015
- Publisher
- WILEY-BLACKWELL
- Keywords
- PDE-423; method validation; pharmacokinetics; LC-MS/MS; rat plasma
- Citation
- BIOMEDICAL CHROMATOGRAPHY, v.29, no.3, pp.321 - 324
- Journal Title
- BIOMEDICAL CHROMATOGRAPHY
- Volume
- 29
- Number
- 3
- Start Page
- 321
- End Page
- 324
- ISSN
- 0269-3879
- Abstract
- A method for determining a novel phosphodiesterase-4 inhibitor, 3-[1-(3cyclopropylmethoxy-4-difluoromethoxybenzyl)-1H-pyrazol-3-yl]-benzoic acid (PDE-423), in rat plasma was developed and validated using liquid chromatography-tandem mass spectrometry for further pharmacokinetic study for development as a novel anti-asthmatic drug. PDE-423 in the concentration range of 0.02-10 mu g/mL was linear with a correlation coefficient of >0.99, and the mean intra- and inter-assay precisions of the assay were 7.50 and 3.86%, respectively. The validated method was used successfully for a pharmacokinetic study of PDE-423 in rats. Copyright (c) 2014 John Wiley & Sons, Ltd.
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Related Researcher
- Cheon, Hyae Gyeong
- College of Medicine (Premedical Course)