Overview of CMOS image sensor use in molecular diagnostics
- Authors
- Devadhasan, Jasmine Pramila; Yoo, In Sang; Kim, Sanghyo
- Issue Date
- Mar-2015
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- CMOS image sensor; Molecular diagnostics; Point-of-care diagnosis; Biochemical detection; Biochip; Nanoparticles
- Citation
- CURRENT APPLIED PHYSICS, v.15, no.3, pp.402 - 411
- Journal Title
- CURRENT APPLIED PHYSICS
- Volume
- 15
- Number
- 3
- Start Page
- 402
- End Page
- 411
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10757
- DOI
- 10.1016/j.cap.2015.01.009
- ISSN
- 1567-1739
- Abstract
- CMOS sensors comprise an important tool in bioscientific applications. This review focuses on CMOS sensor-based molecular diagnostics of DNA, protein, and metabolic molecules. Herein, gene sequencing, DNA-DNA hybridization, single nucleotide polymorphisms (SNP), protein interactions, peptide interactions, antigen-antibody (Ag-Ab) interactions, as well as glucose and cholesterol monitoring using CMOS sensors are discussed along with existing experimental outcomes. CMOS sensor based electrochemical, optical, impedance, dual, continuous, and label-free analysis and their related integration techniques are explained. Moreover, we describe the utilization of a CMOS chip in microarray fabrication, assay platform development, and transducer incorporation for molecular diagnostics. Furthermore, CMOS sensor-based point-of-care (POC) applications, other biological analyses, and the role of nanoparticles in biomolecular sensing are discussed. Future directions include information about the novel integration of CMOS sensor-based molecular diagnostic devices with a central focus towards enhancement of POC approaches. This review is helpful in creating highly sensitive, cheaper, and user-friendly biomedical devices with modern dimensions. (C) 2015 Elsevier B.V. All rights reserved.
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