Role of the focal adhesion protein TRIM15 in colon cancer development
- Authors
- Lee, Ok-Hee; Lee, Jinkyoung; Lee, Keun Ho; Woo, Yun Mi; Kang, Ju-Hee; Yoon, Ho-Geun; Bae, Soo-Kyung; Songyang, Zhou; Oh, Seung Hyun; Choi, Youngsok
- Issue Date
- Feb-2015
- Publisher
- ELSEVIER
- Keywords
- TRIM15; Colon cancer; Focal adhesion; Cell migration
- Citation
- BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v.1853, no.2, pp.409 - 421
- Journal Title
- BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Volume
- 1853
- Number
- 2
- Start Page
- 409
- End Page
- 421
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10822
- DOI
- 10.1016/j.bbamcr.2014.11.007
- ISSN
- 0167-4889
- Abstract
- The tripartite motif containing (TRIM) proteins are a large family of proteins that have been implicated in many biological processes including cell differentiation, apoptosis, transcriptional regulation, and signaling pathways. Here, we show that TRIM15 co-localized to focal adhesions through homo-dimerization and significantly suppressed cell migration. Domain mapping analysis indicated that B-box2 and PRY domains were essential for TRIM15 localization to focal adhesions and inhibition of cell migration. Our protein-protein interaction screen of TRIM15 with the integrin adhesome identified several TRIM15 interacting proteins including coronin 18, cortactin, filamin binding LIM protein1, and vasodilator-stimulated phosphoprotein, which are involved in actin cytoskeleton dynamics. TRIM15 expression was tissue-restricted and downregulated in colon cancer. Level of TRIM15 expression was associated with colon cancer cell migration, as well as both in vitro and in vivo tumor growth. These data provide novel insights into the role of TRIM15 as an additional component of the integrin adhesome, regulating cell migration, and suggest that TRIM15 may function as a tumor suppressor of colon cancer. (C) 2014 Elsevier B.V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10822)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.