Influenza mimetic protein-polymer nanoparticles as antigen delivery vehicles to dendritic cells for cancer immunotherapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Chaeyeon | - |
dc.contributor.author | Jose, Leeja | - |
dc.contributor.author | Shim, KyuHwan | - |
dc.contributor.author | An, Seong Soo A. | - |
dc.contributor.author | Jang, Sunah | - |
dc.contributor.author | Song, Jae Kwang | - |
dc.contributor.author | Jin, Jun-O | - |
dc.contributor.author | Paik, Hyun-jong | - |
dc.date.available | 2020-02-27T02:22:59Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-08-07 | - |
dc.identifier.issn | 2040-3364 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1087 | - |
dc.description.abstract | Stimulation of dendritic cells (DCs) by antigens (Ags) promotes an Ag-specific immune response that kills Ag-expressing pathogens. These biologically inspired nanocarriers have received much attention as tools to deliver cancer Ags to DCs. A polymer-templated protein nanoball having hemagglutinin (H1-NB) that mimics the influenza virus can be used as a cancer Ag delivery vehicle, as DCs show effective phagocytic activities against H1-NB without any adjuvant. In the present study, H1-NB containing ovalbumin (OVA), a model Ag (H1-OVA-NB), was prepared as an anti-cancer agent and evaluated for its effect on anticancer immunity. H1-OVA-NB treatments in C57BL/6 mice enhanced OVA-specific immune activation and efficiently inhibited B16-OVA tumor growth compared to control groups. Our results indicate that H1-NB is an effective carrier for Ag delivery to DCs and promotes immunotherapy to fight cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | NANOSCALE | - |
dc.subject | STRATEGIES | - |
dc.subject | ADJUVANT | - |
dc.subject | VACCINE | - |
dc.subject | SYSTEM | - |
dc.subject | SIZE | - |
dc.title | Influenza mimetic protein-polymer nanoparticles as antigen delivery vehicles to dendritic cells for cancer immunotherapy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000477704400018 | - |
dc.identifier.doi | 10.1039/c9nr03510a | - |
dc.identifier.bibliographicCitation | NANOSCALE, v.11, no.29, pp.13878 - 13884 | - |
dc.identifier.scopusid | 2-s2.0-85069678410 | - |
dc.citation.endPage | 13884 | - |
dc.citation.startPage | 13878 | - |
dc.citation.title | NANOSCALE | - |
dc.citation.volume | 11 | - |
dc.citation.number | 29 | - |
dc.contributor.affiliatedAuthor | Shim, KyuHwan | - |
dc.contributor.affiliatedAuthor | An, Seong Soo A. | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | ADJUVANT | - |
dc.subject.keywordPlus | VACCINE | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | SIZE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.