Influenza mimetic protein-polymer nanoparticles as antigen delivery vehicles to dendritic cells for cancer immunotherapy
- Authors
- Lee, Chaeyeon; Jose, Leeja; Shim, KyuHwan; An, Seong Soo A.; Jang, Sunah; Song, Jae Kwang; Jin, Jun-O; Paik, Hyun-jong
- Issue Date
- 7-Aug-2019
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- NANOSCALE, v.11, no.29, pp.13878 - 13884
- Journal Title
- NANOSCALE
- Volume
- 11
- Number
- 29
- Start Page
- 13878
- End Page
- 13884
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1087
- DOI
- 10.1039/c9nr03510a
- ISSN
- 2040-3364
- Abstract
- Stimulation of dendritic cells (DCs) by antigens (Ags) promotes an Ag-specific immune response that kills Ag-expressing pathogens. These biologically inspired nanocarriers have received much attention as tools to deliver cancer Ags to DCs. A polymer-templated protein nanoball having hemagglutinin (H1-NB) that mimics the influenza virus can be used as a cancer Ag delivery vehicle, as DCs show effective phagocytic activities against H1-NB without any adjuvant. In the present study, H1-NB containing ovalbumin (OVA), a model Ag (H1-OVA-NB), was prepared as an anti-cancer agent and evaluated for its effect on anticancer immunity. H1-OVA-NB treatments in C57BL/6 mice enhanced OVA-specific immune activation and efficiently inhibited B16-OVA tumor growth compared to control groups. Our results indicate that H1-NB is an effective carrier for Ag delivery to DCs and promotes immunotherapy to fight cancer.
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Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
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