Analysis of ImmunoCAP® ISAC results of chronic spontaneous urticaria patients: Comparison with skin prick and the MAST-EIA tests만성 두드러기 환자에서 ImmunoCAPⓇ ISAC 검사에 의한 알레르겐 특이항체 검사 유용성의 분석: 피부단자시험 및MAST-EIA 검사와의 비교 연구
- Other Titles
- 만성 두드러기 환자에서 ImmunoCAPⓇ ISAC 검사에 의한 알레르겐 특이항체 검사 유용성의 분석: 피부단자시험 및MAST-EIA 검사와의 비교 연구
- Authors
- Kim, J.-H.; Roh, J.-Y.; Lee, J.-R.
- Issue Date
- Nov-2015
- Publisher
- Korean Dermatological Association
- Keywords
- Chronic spontaneous urticaria; ImmunoCAP®ISAC; MAST-EIA
- Citation
- Korean Journal of Dermatology, v.53, no.9, pp.684 - 692
- Journal Title
- Korean Journal of Dermatology
- Volume
- 53
- Number
- 9
- Start Page
- 684
- End Page
- 692
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11058
- ISSN
- 0494-4739
- Abstract
- Background: In vivo and/or in vitro diagnostic tests to identify possible allergens have been conducted for patients with chronic spontaneous urticaria (CSU) in order to identify any predisposing factors and avoid unnecessary restrictions. Objective: The purpose of this study was to evaluate the diagnostic effectiveness of ImmunoCAP® ISAC (ISAC) in CSU patients. Methods: A total of 31 patients with CSU were tested by ISAC and Multiple Allergen Simultaneous Test enzyme immunoassays (MAST-EIA). A skin prick test (SPT) was performed for 17 out of 31 patients. The results of ISAC and MAST-EIA were evaluated based on the SPT results. Results: For 17 patients, with SPT used as the reference standard, ISAC compared with MAST-EIA showed lower sensitivity (22.2% vs. 26.5%), higher specificity (100% vs. 95.7%), higher positive predictive value (100% vs. 52.9%), and lower negative predictive value (86.9% vs. 87.7%). The agreement rate was more favorable for ISAC than for MAST-EIA (87.3% vs. 85.1%; kappa=0.324 vs. 0.263). For 31 patients, the agreement rate between ISAC and MAST-EIA was 83.9% for both Dermatophagoides farinae and Dermatophagoides pteronyssinus. Correlation coefficients (Rho) between ISAC and MAST-EIA for each allergen were 0.690 and 0.675, respectively. Conclusion: For CSU patients, specificity, positive predictive value, and the agreement rate of ISAC were similar or superior to those of MAST-EIA. In addition, ISAC provides valuable information on the possible sensitization to different allergen sources by elucidating cross-reactive components. With careful clinical correlations in interpretation, ISAC can be a useful diagnostic tool to detect allergens in CSU patients.
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