Active Molecular Chitosan (AMC-S1): Preparation and Characterization of Antibacterial Activity
- Authors
- 김주원; 이춘근; 황유진; 박제권
- Issue Date
- 2015
- Publisher
- 한국키틴키토산학회
- Keywords
- Active molecular chitosan (AMC-S1); Chitosanase; MALDI-TOF MS; Candida albicans; antibacterial activity
- Citation
- Journal of Chitin and Chitosan, v.20, no.4, pp.280 - 286
- Journal Title
- Journal of Chitin and Chitosan
- Volume
- 20
- Number
- 4
- Start Page
- 280
- End Page
- 286
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11242
- DOI
- 10.17642/jcc.20.4.9
- ISSN
- 1229-4160
- Abstract
- The aim of the present study is to prepare the chitosan hydrolysates and characterize their potential antibacterial activity. High molecular weight chitosan (CTSN-H) and medium molecular weight chitosan (MMWC, 2~10-kDa) were further degraded efficiently by using chitosanase from Bacillus subtilis JH-1122. Molecular weight (MW) of the final product was determined by MALDI-TOF MS, showed several peaks ranging from 0.8 to 2.5-kDa. Based on antibacterial activity of the hydrolysates, final products were named as active molecular chitosan (AMC-S1). AMC-S1 was evaluated as IC50 to 12.5 μg/mL of the concentration toward Candida albicans. Our present study demonstrates that AMC-S1 derived from the digestion of CTSN-H and MMWC can be selected as a potent factor affecting on antimicrobial activity against C. albicans for the industry and pharmaceutical applications.
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Collections - 바이오나노대학 > 생명과학과 > 1. Journal Articles
- 보건과학대학 > 의용생체공학과 > 1. Journal Articles
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