柴胡와 酸漿 복합제가 LPS로 유도된 우울증에 미치는 효과Effect of Mixture extracted from Bupleuri Radix and Physalidis Herba on the LPS-induced depression in Rats.
- Other Titles
- Effect of Mixture extracted from Bupleuri Radix and Physalidis Herba on the LPS-induced depression in Rats.
- Authors
- 이원행; 김도훈; 이태희
- Issue Date
- 2015
- Publisher
- 대한본초학회
- Keywords
- Bupleuri Radix; Physalidis Herba; LPS; anti-depressant; HPA axis
- Citation
- 대한본초학회지, v.30, no.3, pp.69 - 76
- Journal Title
- 대한본초학회지
- Volume
- 30
- Number
- 3
- Start Page
- 69
- End Page
- 76
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11585
- ISSN
- 1229-1765
- Abstract
- Objectives : The effect of mixture extracted from Bupleuri Radix and Physalidis Herba(BR+RH) on the LPS-induced Depression in rats was investigated.
Methods : Rats were administered intragastrically BR+PH after injectio of LPS to induce deprssion. Immobility was examined using Tail Suspension Test(TST), Forced Swimming Test(FST). The level of plasma corticosterone was measured by an Enzyme-Linked Immunosorbent Assay(ELISA) method. The expressions of c-Fos, Corticotropin Releasing Factor(CRF), NADPH-d in the Paraventricular nucleus(PVN) and TH in the Locus coeruleus(LC) were measured by immunohistochemical method.
Results : In the effect of BR+PH on TST, immobility was significantly decreased comparing with the LPS group. In FST, immobility was shown decrease tendency in the BR+PH group. The expression of c-Fos in the PVN was significantly decreased at BR+PH400 group, comparing with the LPS group. The expression of CRF in PVN was shown dto have the decrease tendency in the BR+PH group, comparing with the LPS group. The expression of NADPH-d in PVN was not significantly decreased at BR+PH groups, comparing with the LPS group. The expression of TH in the LC was shown to have the decrease tendency at BR+RH groups, but not significantly, comparing with the LPS group.
Conclusions : Anti-depressant effect of mixture after extracted from Bupleuri Radix and Physalidis Herba was through the anti-inflammatory effect via inhibition of HPA axis. NO and catecholamine system is not involved.
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