AP-1-Targeting Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis
- Authors
- Hossen, Muhammad Jahangir; Kim, Seung Cheol; Son, Young-Jin; Baek, Kwang-Soo; Kim, Eunji; Yang, Woo Seok; Jeong, Deok; Park, Jae Gwang; Kim, Han Gyung; Chung, Woo-Jae; Yoon, Keejung; Ryou, Chongsuk; Lee, Sang Yeol; Kim, Jong-Hoon; Cho, Jae Youl
- Issue Date
- 2015
- Publisher
- HINDAWI LTD
- Citation
- EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
- Journal Title
- EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11917
- DOI
- 10.1155/2015/608126
- ISSN
- 1741-427X
- Abstract
- In traditional Chinese medicine, Persicaria chinensis L. has been prescribed to cure numerous inflammatory disorders. We previously analyzed the bioactivity of the methanol extract of this plant (Pc-ME) against LPS-induced NO and PGE(2) in RAW264.7 macrophages and found that it preventedHCl/EtOH-induced gastric ulcers in mice. The purpose of the current study was to explore the molecular mechanism by which Pc-ME inhibits activator protein-(AP-) 1 activation pathway and mediates its hepatoprotective activity. To investigate the putative therapeutic properties of Pc-ME against AP-1-mediated inflammation and hepatotoxicity, lipopolysaccharide-(LPS-) stimulated RAW264.7 and U937 cells, a monocyte-like human cell line, and an LPS/D-galactosamine(D-GalN-) induced acute hepatitis mouse model were employed. The expression of LPS-induced proinflammatory cytokines including interleukin-(IL-) 1 beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) was significantly diminished by Pc-ME. Moreover, Pc-ME reduced AP-1 activation and mitogen-activated protein kinase (MAPK) phosphorylation in both LPS-stimulated RAW264.7 cells and differentiated U937 cells. Additionally, we highlighted the hepatoprotective and curative effects of Pc-ME pretreated orally in a mouse model of LPS/D-GalN-intoxicated acute liver injury by demonstrating the significant reduction in elevated serum AST and ALT levels and histological damage. Therefore, these results strongly suggest that Pc-ME could function as an antihepatitis remedy suppressing MAPK/AP-1-mediated inflammatory events.
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