Dopamine-functionalized InP/ZnS quantum dots as fluorescence probes for the detection of adenosine in microfluidic chip
- Authors
- Ankireddy, Seshadri Reddy; Kim, Jongsung
- Issue Date
- Aug-2015
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- quantum dots; photoluminescence; microfluidic chip; adenosine; mercaptopropionic acid; mercaptoundecanoic acid; PDMS
- Citation
- INTERNATIONAL JOURNAL OF NANOMEDICINE, v.10, pp.121 - 128
- Journal Title
- INTERNATIONAL JOURNAL OF NANOMEDICINE
- Volume
- 10
- Start Page
- 121
- End Page
- 128
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11975
- DOI
- 10.2147/IJN.S88465
- ISSN
- 1178-2013
- Abstract
- Microbeads are frequently used as solid supports for biomolecules such as proteins and nucleic acids in heterogeneous microfluidic assays. Chip-based, quantum dot (QD)-bead-biomolecule probes have been used for the detection of various types of DNA. In this study, we developed dopamine (DA)-functionalized InP/ZnS QDs (QDs-DA) as fluorescence probes for the detection of adenosine in microfluidic chips. The photoluminescence (PL) intensity of the QDs-DA is quenched by Zn2+ because of the strong coordination interactions. In the presence of adenosine, Zn2+ cations preferentially bind to adenosine, and the PL intensity of the QDs-DA is recovered. A polydimethylsiloxane-based microfluidic chip was fabricated, and adenosine detection was confirmed using QDs-DA probes.
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Collections - 공과대학 > 화공생명공학과 > 1. Journal Articles
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