Bioactive Lignan Constituents from the Twigs of Lindera glauca
- Authors
- Kim, Ki Hyun; Moon, Eunjung; Ha, Sang Keun; Suh, Won Se; Kim, Ho Kyung; Kim, Sun Yeou; Choi, Sang Un; Lee, Kang Ro
- Issue Date
- Nov-2014
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- Lindera glauca; Lauraceae; lignan; cytotoxicity; anti-inflammation
- Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN, v.62, no.11, pp.1136 - 1140
- Journal Title
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Volume
- 62
- Number
- 11
- Start Page
- 1136
- End Page
- 1140
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12150
- DOI
- 10.1248/cpb.c14-00381
- ISSN
- 0009-2363
- Abstract
- A bioassay-guided fractionation and chemical investigation of the MeOH extract from the twigs of Lindera glauca (SIEB. et ZUCC.) BLUME resulted in the isolation and identification of six lignans (1-6) including three new lignan derivatives, named linderuca A (1), B (2), and C (3). The structures of the new compounds (1-3) were determined on the basis of spectroscopic analyses, including two dimensional NMR and circular dichroism (CD) spectroscopy studies. The cytotoxic activities of the isolates (1-6) were evaluated by determining their inhibitory effects on human tumor cell lines. Compounds 1-5 showed antiproliferative activities against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values of 7.79-29.42 mu M. Based on the understanding that inflammation is a crucial cause of tumor progression, we also investigated the anti-inflammatory activities of the isolates (1-6) in the lipopolysaccharide-stimulated murine microglia BV-2 cell line by measuring nitric oxide (NO) levels. The new lignans (1-3) significantly inhibited NO production with IC50 values of 12.10, 9.48, and 9.87 mu M, respectively, without cytotoxicity.
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