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The first synthesis of the antiangiogenic homoisoflavanone, cremastranone
- Authors
- Lee, Bit; Basavarajappa, Halesha D.; Sulaiman, Rania S.; Fei, Xiang; Seo, Seung-Yong; Corson, Timothy W.
- Issue Date
- 21-Oct-2014
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- ORGANIC & BIOMOLECULAR CHEMISTRY, v.12, no.39, pp.7673 - 7677
- Journal Title
- ORGANIC & BIOMOLECULAR CHEMISTRY
- Volume
- 12
- Number
- 39
- Start Page
- 7673
- End Page
- 7677
- ISSN
- 1477-0520
- Abstract
- An antiangiogenic homoisoflavanone, cremastranone, was synthesized for the first time. This scalable synthesis, which includes selective demethylation, could be used to develop lead molecules to treat angiogenesis-induced eye diseases. Synthetic cremastranone inhibited the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells, important steps in pathological angiogenesis.
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Related Researcher
- Seo, Seung Yong
- Pharmacy (Dept.of Pharmacy)