Comparison of Clinical Manifestations, Outcomes and Cerebrospinal Fluid Findings Between Herpes Simplex Type 1 and Type 2 Central Nervous System Infections in Adults
- Authors
- Moon, Song Mi; Kim, Tark; Lee, Eun Mi; Kang, Joong Koo; Lee, Sang-Ahm; Choi, Sang-Ho
- Issue Date
- Oct-2014
- Publisher
- WILEY-BLACKWELL
- Keywords
- herpes simplex virus; meningitis; encephalitis
- Citation
- JOURNAL OF MEDICAL VIROLOGY, v.86, no.10, pp.1766 - 1771
- Journal Title
- JOURNAL OF MEDICAL VIROLOGY
- Volume
- 86
- Number
- 10
- Start Page
- 1766
- End Page
- 1771
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12225
- DOI
- 10.1002/jmv.23999
- ISSN
- 0146-6615
- Abstract
- In previous reports on the viral causes of central nervous system (CNS) infections, it has been generally recognized that HSV-1 is a major cause of encephalitis, while HSV-2 is the predominant cause of aseptic meningitis in adults. To examine this matter, the clinical characteristics in the two types of HSV CNS infections were investigated. In a retrospective cohort study which included all adult patients (>= 16 years) between January 1999 and December 2013 in a 2,700-bed tertiary care hospital, all the patients in whom PCR of the CSF for HSV was positive were identified. Ninety-five patients with positive CSF PCR results for HSV were included, 21 with HSV-1 and 74 with HSV-2. Many patients with HSV-1 had encephalitis (13/21, 61.9%), whereas most patients with HSV-2 had meningitis (62/74, 83.8%). However, HSV-1 and HSV-2 accounted for similar proportion of patients with HSV encephalitis (13/25, 52.0% vs. 12/25, 48.0%). Neurological sequelae were more frequent among patients with HSV-1 (9/21, 42.9% vs. 6/74, 8.1%; P = 0.001). The present study suggests that HSV-2 is not only a major cause of aseptic meningitis, but also it may cause serious manifestation as HSV-1 encephalitis in adults. (C) 2014 Wiley Periodicals, Inc.
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