Nocatriones A and B, Photoprotective Tetracenediones from a Marine-Derived Nocardiopsis sp.
- Authors
- Kim, Min Cheol; Hwang, Eunson; Kim, Taejung; Ham, Jungyeob; Kim, Sun Yeou; Kwon, Hak Cheol
- Issue Date
- Oct-2014
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.77, no.10, pp.2326 - 2330
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 77
- Number
- 10
- Start Page
- 2326
- End Page
- 2330
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12258
- DOI
- 10.1021/np5006086
- ISSN
- 0163-3864
- Abstract
- Two new tetracenedione derivatives, nocatriones A (1) and B (2), were discovered from the culture broth of a marine actinomycete, Nocardiopsis sp. KMF-002, which was isolated from the tissue of an unidentified dark purple marine sponge. The structures of 1 and 2, which are tetracenediones containing a-pyrone substituents, were determined to be 3,8,10,11-tetrahydroxy-2-(4-hydroxy-2-oxo-2H-pyran-6-yl)-1-methyltetracene-5,12-dione (1) and 3,8,10,12-tetrahydroxy-2-(4-hydroxy-2-oxo-2H-pyran-6-yl)-1-methyltetracene-6,11-dione (2). Ultraviolet B (UVB)-irradiated cells treated with 10 mu M nocatrione A (1) significantly decreased the level of MMP-1, a protein that degrades collagen and other extracelluar matrix components that comprise dermal tissue, when compared to untreated cells. These results support that nocatriones A (1) and B (2) may show antiphotoaging activity in UVB-irradiated models.
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