Extract of Litsea japonica ameliorates blood-retinal barrier breakdown in db/db mice
- Authors
- Kim, Junghyun; Kim, Chan-Sik; Lee, Ik Soo; Lee, Yun Mi; Sohn, Eunjin; Jo, Kyuhyung; Kim, Joo Hwan; Kim, Jin Sook
- Issue Date
- Aug-2014
- Publisher
- SPRINGER
- Keywords
- Blood-retinal barrier; Diabetic retinopathy; Litsea japonica; Vascular endothelial growth factor; Occludin
- Citation
- ENDOCRINE, v.46, no.3, pp.462 - 469
- Journal Title
- ENDOCRINE
- Volume
- 46
- Number
- 3
- Start Page
- 462
- End Page
- 469
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12443
- DOI
- 10.1007/s12020-013-0085-x
- ISSN
- 1355-008X
- Abstract
- Loss of blood-retinal barrier (BRB) properties is an important feature in the pathology of diabetic retinopathy. Endothelium integrity is important for the normal vascular function. Litsea japonica (Thunb.) Jussieu is a Korean native plant that is consumed as a vegetable food. In this study, we evaluated the ability of an ethanol extract of L. japonica to prevent retinal vascular leakages in db/db mice, which is an animal model of type II diabetes. L. japonica extracts (LJE, 100 and 250 mg/kg) were administered once a day, orally, for 12 weeks. Vehicle-treated db/db mice exhibited hyperglycemia and retinal vascular leakage. LJE treatment blocked diabetes-induced BRB breakdown and decreased retinal VEGF expression in db/db mice. LJE also inhibited the degradation of occludin, which is an important tight junction protein. These findings support the potential therapeutic usefulness of L. japonica for retinal vascular permeability diseases.
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