beta-Catenin Activated Hepatocellular Adenoma: A Report of Three Cases in Korea
- Authors
- Kim, Gi Jeong; Seok, Jae Yeon; Rhee, Hyungjin; Choi, Jin-Young; Choi, Jin-Sub; Kim, Kyung Sik; Thung, Swan; Park, Young Nyun
- Issue Date
- Jul-2014
- Publisher
- EDITORIAL OFFICE GUT & LIVER
- Keywords
- Adenoma; liver cell; Beta catenin; Carcinoma; hepatocellular; Glutamine synthetase
- Citation
- GUT AND LIVER, v.8, no.4, pp.452 - 458
- Journal Title
- GUT AND LIVER
- Volume
- 8
- Number
- 4
- Start Page
- 452
- End Page
- 458
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12521
- DOI
- 10.5009/gnl.2014.8.4.452
- ISSN
- 1976-2283
- Abstract
- Hepatocellular adenoma (HCA) is an uncommon benign hepatic tumor, and the use of oral contraceptives is known to contribute to the development of HCA. Recently, a genotype and phenotype classification system for HCA was suggested, and Malignant transformation to hepatocellular carcinoma (HCC) was shown to be strongly associated with activating mutations in beta-catenin. Here, we report three cases of HCA in Korean patients: 7-cm, inflammatory and beta-catenin-activated HCA with HCC transformation in a 46-year-old man; 13-cm, beta-catenin-activated HCA with cytological atypia in a 23-year-old woman; and 10-cm, pigmented, inflammatory and p-catenin-activated HCA in a 36-year-old man. All cases exhibited the nuclear expression of beta-catenin and diffuse cytoplasmic expression of glutamine synthetase upon immunohistochemical staining. All tumors were completely resected, and the patients were followed for 3 to 6 years with no evidence of local recurrence or metastasis.
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