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BMP2 shows neurotrophic effects including neuroprotection against neurodegeneration
- Issue Date
- 28-May-2014
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- bone morphogenetic protein 2; microtubule; neuroprotection; PI3K; PTEN
- Citation
- NEUROREPORT, v.25, no.8, pp.549 - 555
- Journal Title
- NEUROREPORT
- Volume
- 25
- Number
- 8
- Start Page
- 549
- End Page
- 555
- ISSN
- 0959-4965
- Abstract
- In this study, we found that BMP2 exerts neurotrophic effects, including a neuroprotective effect against nocodazole-induced neuritic degeneration, on neuronal cells. We also found that BMP2-induced neurotrophic effects are directly involved in Smad-dependent signaling as well as PI3K/PTEN-Akt-mTOR signaling. Moreover, BMP2-induced neurotrophic effects occur by stabilization of neuronal microtubules. Thus, these findings suggest that BMP2 can be a potential therapeutic target for nerve injury treatment.
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