Unusual Expression of Thyroid Transcription Factor 1 and Napsin A in Metastatic Adenoid Cystic Carcinoma of Extrapulmonary Origin in the Lung
- Authors
- An, Jungsuk; Park, Sanghui; Sung, Sun Hee; Cho, Min-Sun; Kim, Seung Cheol
- Issue Date
- May-2014
- Publisher
- AMER SOC CLINICAL PATHOLOGY
- Keywords
- Adenoid cystic carcinoma; Thyroid transcription factor 1; Napsin A; Immunohistochemistry
- Citation
- AMERICAN JOURNAL OF CLINICAL PATHOLOGY, v.141, no.5, pp.712 - 717
- Journal Title
- AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- Volume
- 141
- Number
- 5
- Start Page
- 712
- End Page
- 717
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12666
- DOI
- 10.1309/AJCPB0YIY6LQLQTG
- ISSN
- 0002-9173
- Abstract
- Objectives: Our study examines thyroid transcription factor I (TTF-1) expression in 40 primary adenoid cystic carcinomas (ACCs) arising in various sites and compares TTF-1 expression between primary and metastatic ACCs in 12 cases with distant metastases. Methods: Forty patients with ACCs, including 12 pairs of primary and metastatic ACCs, were evaluated for the immunohistochemical expression of TTF-1 (clone SPT24). In addition, 10 metastatic ACCs to the lung were tested on napsin A and a different TTF-1 antibody (clone 8G7G3) for further evaluation. Results: No primary ACCs showed TTF-1 immunoreactivity (clone SPT24). TTF-1 was positive in five (41.7%) of 12 metastatic ACCs; all five cases were found only in the lung and comprised five (50.0%) of 10 cases. In all positive cases, staining was focal and detected only in the cribriform histologic subtype. Staining patterns using both antibodies (both SPT24 and 8G7G3) were very similar, and TTF-1 positive tumor cells were also positive for napsin A. Extrapulmonary ACCs were all negative for TTF-1 regardless of origination and metastasis. Conclusions: TTF-1-and napsin A-positive ACCs in the lung should not be considered primary ACCs because TTF-1 and napsin A can be expressed in metastatic ACCs of the lung.
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