Photoluminescent carbon nanotags from harmful cyanobacteria for drug delivery and imaging in cancer cells
- Authors
- Lee, Hyun Uk; Park, So Young; Park, Eun Sik; Son, Byoungchul; Lee, Soon Chang; Lee, Jae Won; Lee, Young-Chul; Kang, Kyoung Suk; Kim, Moon Il; Park, Hyun Gyu; Choi, Saehae; Huh, Yun Suk; Lee, Seung-Yeul; Lee, Kyung-Bok; Oh, You-Kwan; Lee, Jouhahn
- Issue Date
- 11-Apr-2014
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v.4
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 4
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12699
- DOI
- 10.1038/srep04665
- ISSN
- 2045-2322
- Abstract
- Using a simple method of mass production of green carbon nanotags (G-tags) from harmful cyanobacteria, we developed an advanced and efficient imaging platform for the purpose of anticancer therapy. Approximately 100 grams of G-tags per 100 kilograms of harmful cyanobacteria were prepared using our eco-friendly approach. The G-tags possess high solubility, excellent photostability, and low cytotoxicity (<1.5 mg/mL for 24 h). Moreover, doxorubicin-conjugated G-tags (T-tags; >0.1 mg/mL) induced death in cancer cells (HepG2 and MCF-7) in-vitro at a higher rate than that of only G-tags while in-vivo mice experiment showed enhanced anticancer efficacy by T-tags at 0.01 mg/mL, indicating that the loaded doxorubicin retains its pharmaceutical activity. The cancer cell uptake and intracellular location of the G- and T-tags were observed. The results indicate that these multifunctional T-tags can deliver doxorubicin to the targeted cancer cells and sense the delivery of doxorubicin by activating the fluorescence of G-tags.
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Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
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