Antiviral Effect of Flavonol Glycosides Isolated from the Leaf of Zanthoxylum piperitum on Influenza Virus
- Authors
- Ha, Song-Yi; Youn, Hana; Song, Chang-Seon; Kang, Se Chan; Bae, Jong Jin; Kim, Hee Tae; Lee, Kwang Min; Eom, Tae Loon; Kim, In Su; Kwak, Jong Hwan
- Issue Date
- Apr-2014
- Publisher
- MICROBIOLOGICAL SOCIETY KOREA
- Keywords
- Zanthoxylum piperitum; Rutaceae; flavonol glycoside; anti-influenza activity; neuraminidase inhibitor
- Citation
- JOURNAL OF MICROBIOLOGY, v.52, no.4, pp.340 - 344
- Journal Title
- JOURNAL OF MICROBIOLOGY
- Volume
- 52
- Number
- 4
- Start Page
- 340
- End Page
- 344
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12738
- DOI
- 10.1007/s12275-014-4073-5
- ISSN
- 1225-8873
- Abstract
- The ethanol extract of Zanthoxylum piperitum (L.) DC. showed in vitro antiviral activity against influenza A virus. Three flavonol glycosides were isolated from the EtOAc fraction of Z. piperitum leaf by means of activity-guided chromatographic separation. Structures of isolated compounds were identified as quercetin 3-O-beta-D-galactopyranoside (1), quercetin 3-O-alpha-L-rhamnopyranoside (2), kaempferol 3-O-alpha-L-rhamnopyranoside (3) by comparing their spectral data with literature values. The anti-influenza viral activity of isolates was evaluated using a plaque reduction assay against influenza A/NWS/33 (H1N1) virus. The compounds also were subjected to neuraminidase inhibition assay in influenza A/NWS/33 virus. Compounds 1-3 exhibited antiviral activity against an influenza A virus in vitro, and inhibited the neuraminidase activity at relatively high concentrations.
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