Identification of Anti-cancer Active Components of Taraxacum coreanum on Human Gastric Cancer AGS Cells
- Authors
- Yamabe, Noriko; Kang, Ki Sung; Lee, Ah Young; Lee, Dahae; Choi, Ji Myung; Lee, Sullim; Park, Jun Yeon; Hwang, Gwi Seo; Kim, Hyun Young; Cho, Eun-Ju; Lee, Sanghyun
- Issue Date
- Apr-2014
- Publisher
- KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
- Keywords
- apoptosis; caspase; gastric cancer; luteolin; Taraxacum coreanum
- Citation
- JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.57, no.2, pp.187 - 190
- Journal Title
- JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
- Volume
- 57
- Number
- 2
- Start Page
- 187
- End Page
- 190
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12758
- DOI
- 10.1007/s13765-014-4031-2
- ISSN
- 1738-2203
- Abstract
- Anti-cancer effects were compared amongst Taraxacum coreanum extract, its fractions, and 7 ingredients (beta-sitosterol, daucosterol, taraxasteryl acetate, chrysoeriol, diosmetin, luteolin, and luteoloside). Exposure to the ethyl acetate fraction (50 and 100 mu g/mL) of T. coreanum extract and luteolin (10 and 50 mu M) for 24 h induced the cleavage of poly (ADP-ribose) polymerase (PARP), caspase-3, and caspase-8, in a dose-dependent manner. These findings demonstrate that luteolin is the main active component of T. coreanum extract activating caspases-3 and -8 which contribute to apoptotic cell death.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 한의과대학 > 한의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12758)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.