Coordination-Driven Self-Assembly and Anticancer Potency Studies of Arene-Ruthenium-Based Molecular Metalla-Rectangles
- Authors
- Mishra, Anurag; Jeong, Yong Joon; Jo, Jae-Ho; Kang, Se Chan; Kim, Hyunuk; Chi, Ki-Whan
- Issue Date
- 10-Mar-2014
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANOMETALLICS, v.33, no.5, pp.1144 - 1151
- Journal Title
- ORGANOMETALLICS
- Volume
- 33
- Number
- 5
- Start Page
- 1144
- End Page
- 1151
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12787
- DOI
- 10.1021/om401042m
- ISSN
- 0276-7333
- Abstract
- The two new large molecular metalla-rectangles 6 and 8 were obtained by the reaction of the two different arene-ruthenium acceptors [Ru-2(p-cymene)(2)(mu-eta(4)-C2O4)Cl-2] (2) and [Ru-2(p-cymene)(2)(donq)(Cl)(2)] (donq = 5,8-dioxido-1,4-naphthoquinonato) (4) with a symmetrical N,N'-bis(4-(pyridin-4-ylethynyl)phenyl)-terephthalamide (1) donor ligand. Both metalla-rectangles were isolated in good yields as triflate salts and were characterized by multinuclear NMR, ESI-MS, and UV-vis spectroscopy. X-ray crystallography of 6 confirmed a molecular metalla-rectangle. The cytotoxicities of metalla-rectangles 6-9 were established in SK-hep-1 (liver cancer), AGS (gastric cancer), and HCT-15 (colorectal cancer) human cancer cell lines. The cytotoxicity of metalla-rectangle 8 was found to be considerably stronger against all cancer cell lines, even much more effective than the well-known anticancer drugs doxorubicin and cisplatin. In addition, expressions of APC and p53, colorectal cancer suppressor genes, were significantly increased following exposure to the metalla-rectangle 8.
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