Current status of pulmonary arterial hypertension in Korea
- Authors
- Jang, Albert Youngwoo; Chung, Wook-Jin
- Issue Date
- Jul-2019
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Keywords
- Pulmonary arterial hypertension; Early diagnosis; Pharmacotherapy; Phenotyping; Precision medicine
- Citation
- KOREAN JOURNAL OF INTERNAL MEDICINE, v.34, no.4, pp.696 - 707
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- Volume
- 34
- Number
- 4
- Start Page
- 696
- End Page
- 707
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1284
- DOI
- 10.3904/kjim.2019.185
- ISSN
- 1226-3303
- Abstract
- Pulmonary arterial hypertension (PAH) is characterized by remodeling of the distal pulmonary arteries resulting in high pulmonary vascular resistance and, eventually, right ventricular heart failure. Although current advances in PAH therapy have improved outcomes, poor survival remains a reality worldwide, including Korea. One of the most important issues in PAH is the late diagnosis, since screening or diagnostic efforts are often overlooked due to the rarity of disease. Data from Korean registries and observational cohorts show that delayed detection leads to increased morbidity. Additionally, low percentages of Korean patients are committed to intensive PAH-targeted therapy. Current Korean health insurance policies' lack of coverage for new PAH-targeted drugs and upfront combination therapy may also hamper the improvement of treatment outcomes. Understanding individual variability in response to therapeutics through deep phenotyping is a novel strategy that should be considered when treating PAH. Overall, early detection of PAH by proactive screening together with early, intensive, individualized PAH therapy using deep phenotyping is crucial for improving prognoses for PAH patients in Korea.
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