A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity
- Authors
- Shin, Myoung-Sook; Yu, Jun Sang; Lee, Jaemin; Ji, Young Seok; Joung, Hee Joung; Han, Yu-Mee; Yoo, Hye Hyun; Kang, Ki Sung
- Issue Date
- Jul-2019
- Publisher
- MDPI
- Keywords
- hydroxypropyl methylcellulose; curcumin; bioavailability; hepatoprotective
- Citation
- BIOMOLECULES, v.9, no.7
- Journal Title
- BIOMOLECULES
- Volume
- 9
- Number
- 7
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1303
- DOI
- 10.3390/biom9070281
- ISSN
- 2218-273X
- Abstract
- Curcumin is a polyphenol compound derived from the rhizomes of Curcuma longa that exhibits antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. However, its low solubility in aqueous solutions, low absorption following oral administration, and rapid degradation limit its use as a functional food material. In this study, a hydroxypropyl methylcellulose-based solid dispersion of curcumin (DW-CUR 20) was prepared and its bioavailability was evaluated. In addition, its therapeutic efficacy as a hepatoprotective agent was investigated using the model of tert-butyl hydroperoxide (t-BHP)-induced hepatocyte damage. The rat plasma pharmacokinetic study showed that the oral curcumin bioavailability of DW-CUR 20 significantly increased compared to that of non-formulated curcumin. DW-CUR 20 showed a concentration-dependent hepatocyte protective effect on t-BHP-induced HepG2 cells. DW-CUR 20 inhibited the release of lactate dehydrogenase and decreased apoptosis-related proteins such as Poly (ADP-ribose) polymerase, cleaved caspase-7 and cleaved caspase-8 on t-BHP-treated HepG2 cells. These findings suggest that DW-CUR 20 could be a promising formulation for enhancing the therapeutic efficiency of curcumin and for improving the safety.
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