갈근이 비만 랫드 간조직의 비만관련 유전자 발현에 미치는 영향The effects of Pueraria lobata extract on gene expression in liver tissue of rat with estrogen-deficient obesity
- Other Titles
- The effects of Pueraria lobata extract on gene expression in liver tissue of rat with estrogen-deficient obesity
- Authors
- 신윤상; 황귀서
- Issue Date
- 2014
- Publisher
- 대한예방한의학회
- Keywords
- Pueriaria lobata; obesity; estrogen; gene expression
- Citation
- 대한예방한의학회지, v.18, no.3, pp.117 - 128
- Journal Title
- 대한예방한의학회지
- Volume
- 18
- Number
- 3
- Start Page
- 117
- End Page
- 128
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13296
- ISSN
- 1226-7066
- Abstract
- Objective : It is known that Pueriaria lobata has an anti-osteoporetic effect, anti-cancer effect, anti-pyretic effect, and anti-diabetic effect. The aim of this study was to evaluate anti-obesity effect of Pueriaria lobata extract (PLE), and elucidate the effect of it on gene expression related to lipid metabolism.
Method : The experiments were performed with the use of ovariectomized rats as estrogen-deficient obesity model. They were grouped NC (normal control), OC (estrogen-deficient control), PLH (100mg/kg of PLE), PLL (20mg/kg). PLE was orally administered for 6 weeks. Body weights and serum lipid level were estimated, and real-time PCR was performed to investigate the effect of PLE on gene expression in liver.
Results : PLE decreased the body weight and serum cholesterol and triglyceride, but increased HDL-cholesterol.
And PLE increased leptin, CYP27, CPT1, CYP8B1, ACAT2, LDLR, and SCD1, but reduced PPARγ, PGC1A, HMG-CoA-R, ACAT1, SCD1, and APoB gene expression in liver tissue of rat with estrogen-deficient obesity.
Conclusion : It is concluded that Pueriaria lobata reduced body weight, and its effect was expressed by regulation of gene expression related to lipid metabolism in rats with estrogen-deficient obesity.
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