導痰湯이 고지혈증 흰쥐의 뇌허혈 손상에 미치는 영향Effects of Dodam-tang on Cerebral Ischemic Damage of Hyperlipidemic Rats
- Other Titles
- Effects of Dodam-tang on Cerebral Ischemic Damage of Hyperlipidemic Rats
- Authors
- 김경훈; 김도훈; 김연섭
- Issue Date
- 2014
- Publisher
- 대한본초학회
- Keywords
- Dodam-tang; iNOS; MMP-9; GFAP; edema; neuroprotective effect
- Citation
- 대한본초학회지, v.29, no.5, pp.23 - 30
- Journal Title
- 대한본초학회지
- Volume
- 29
- Number
- 5
- Start Page
- 23
- End Page
- 30
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13444
- ISSN
- 1229-1765
- Abstract
- Objectives : Dodam-tang has been reported to have a control effect against the hyperlipidemia and thrombosis. Based upon these previous reports, this study investigates the effects of Dodam-tang on the cerebral ischemic damage of the hyperlipidemic rats.
Methods : Hyperlipidemia was induced by the beef tallow 30% diet for 14 days on Sprague-Dawley rats. Ischemic damage was induced by the middle cerebral artery occlusion (MCAO) for 2 hours with the intraluminal thread method. Then water extract of Dodam-tang was administered daily for 5 days. The effect of Dodam-tang was evaluated with the serum lipids, infarct volume and edema percentage, and immunohistochemical expressions of iNOS, MMP-9, and GFAP in the brain tissue.
Results : The obtained results were as follows; Dodam-tang reduced significantly the infarct size in a TTC-stained 5th brain section of the hyperlipidemic MCAO rats. Dodam-tang suppressed the infarct volume of the hyperlipidemic MCAO rats, but not significant statistically. Dodam-tang suppressed the edema percentage of the hyperlipidemic MCAO rats significantly in the brain tissue. Dodam-tang suppressed significantly the iNOS expression in the cerebral penumbra and caudate putamen of the hyperlipidemic MCAO rats. Dodam-tang suppressed significantly the MMP-9 expression in the cerebral penumbra of the hyperlipidemic MCAO rats. Dodam-tang suppressed significantly the GFAP-expressed atrocytes in the cerebral penumbra of the hyperlipidemic MCAO rats.
Conclusions : These results suggest that Dodam-tang suppresses the brain edema formation through the suppression of the iNOS, MMP-9 and GFAP, but the neuroprotective effect against the cerebral infarct are not distinct.
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