황금, 인동등 추출물 혼합의 항염효능에 관한 in vitro 연구Anti-inflammatory Effect of Combination of Scutellariae Radix and Lonicerae Caulis Water Extract
- Other Titles
- Anti-inflammatory Effect of Combination of Scutellariae Radix and Lonicerae Caulis Water Extract
- Authors
- 하유군; 최유경
- Issue Date
- 2014
- Publisher
- 한의병리학회
- Keywords
- Scutellariae Radix; Lonicerae Caulis; anti-inflammation; NO; TNF-α; MIP-1α; MIP-1β; MIP-2
- Citation
- 동의생리병리학회지, v.28, no.3, pp.330 - 336
- Journal Title
- 동의생리병리학회지
- Volume
- 28
- Number
- 3
- Start Page
- 330
- End Page
- 336
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13576
- ISSN
- 1738-7698
- Abstract
- This study aimed at examining the anti-inflammatory effects of Scutellariae Radix & Lonicerae Caulis water extract(SC). RAW 264.7 mouse macrophage cells were treated with 25∼200㎍/㎖ SC for 24 hours. Cell viability was then measured using MTT assays. The nitric oxide(NO) production and the creation of several cytokines in LPS-stimulated RAW 264.7 cells were investigated. SC inhibited significantly increasing the production of NO in LPS-induced RAW 264.7 cell at the density of 25, 50 and 200 ㎍/㎖. SC inhibited significantly the TNF-α of the RAW 264.7 cell induced by LPS at the density of 50㎍/㎖. SC inhibited significantly the MIP-1α of the RAW 264.7 cell induced by LPS at the density of 25, 50 and 100㎍/㎖. SC inhibited significantly the MIP-1β, MIP-2 at the density of 50, 100㎍/㎖ in the RAW 264.7 cell increased by LPS, respectively. SC did not affect the production levels of VEGF in RAW 264.7 cell. As a result, SC significantly inhibited the inductions of MIP-1α, MIP-1β, MIP-2 and NO in LPS-induced RAW 264.7 cell without causing the toxicity. These results signify that SC has anti-inflammatory effects on controlling the over inflammatory reaction on the RAW 264.7 cell.
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