Inhibitory Effect of Bee Venom Toxin on the Growth of Cervix Cancer C33A Cells via Death Receptor Expression and Apoptosis
- Authors
- 고성철; 송호섭
- Issue Date
- 2014
- Publisher
- 대한침구의학회
- Keywords
- Bee venom; Cervix cancer; C33A; Death receptor; Apoptosis
- Citation
- Journal of Acupuncture Research, v.31, no.2, pp.75 - 85
- Journal Title
- Journal of Acupuncture Research
- Volume
- 31
- Number
- 2
- Start Page
- 75
- End Page
- 85
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13678
- ISSN
- 2586-288X
- Abstract
- Objectives : We investigated whether bee venom(BV) inhibit cell growth through enhancement of death receptor expressions in the human cervix cancer C33A cells.
Methods : BV(1~5 ㎍/㎖) inhibited the growth of cervix cancer C33A cells by the induction of apoptotic cell death in a dose dependent manner.
Results : Consistent with apoptotic cell death, expression of Fas, death receptor(DR) 3, 4, 5 and 6 was increased concentration dependently in the cells. Moreover, Fas, DR3 and DR6 revealed more sensitivity to BV. Thus, We reconfirmed whether they actually play a critical role in anti-proliferation of cervix cancer C33A cells. Consecutively, expression of DR downstream pro-apoptotic proteins including caspase-8, -3, -9 was upregulated and Bax was concomitantly overwhelmed the expression of Bcl-2. NF-κB were also inhibited by treatment with BV in C33A cells.
Conclusions : These results suggest that BV could exert anti-tumor effect through induction of apoptotic cell death in human cervix cancer C33A cells via enhancement of death receptor expression, and that BV could be a promising agent for preventing and treating cervix cancer.
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