Enantioselective synthesis of alpha-halo-alpha-alkylmalonates via phase-transfer catalytic alpha-alkylation
- Authors
- Hong, Suckchang; Kim, Minsik; Jung, Myunggi; Ha, Min Woo; Lee, Myungmo; Park, Yohan; Kim, Mi-hyun; Kim, Taek-Soo; Lee, Jihoon; Park, Hyeung-geun
- Issue Date
- Mar-2014
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- ORGANIC & BIOMOLECULAR CHEMISTRY, v.12, no.9, pp.1510 - 1517
- Journal Title
- ORGANIC & BIOMOLECULAR CHEMISTRY
- Volume
- 12
- Number
- 9
- Start Page
- 1510
- End Page
- 1517
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14035
- DOI
- 10.1039/c3ob42107d
- ISSN
- 1477-0520
- Abstract
- A new enantioselective synthetic method for alpha-halo-alpha-alkylmalonates is reported. alpha-Alkylation of diphenylmethyl tert-butyl alpha-halomalonates under phase-transfer catalytic conditions (solid KOH, toluene, -40 degrees C) in the presence of (S,S)-3,4,5-trifluorophenyl-NAS bromide (5 mol%) afforded diphenylmethyl tert-butyl alpha-halo-alpha-alkylmalonates in very high chemical yields (up to 99%) and optical yields (up to 93% ee).
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14035)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.