2,4-Di-tert-butylphenol from Sweet Potato Protects Against Oxidative Stress in PC12 Cells and in Mice
- Authors
- Choi, Soo Jung; Kim, Jae Kyeom; Kim, Hye Kyung; Harris, Keith; Kim, Chang-Ju; Park, Gwi Gun; Park, Cheung-Seog; Shin, Dong-Hoon
- Issue Date
- 1-Nov-2013
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- Alzheimer' s disease; amyloid beta peptide; oxidative stress; PC12 cells
- Citation
- JOURNAL OF MEDICINAL FOOD, v.16, no.11, pp.977 - 983
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- Volume
- 16
- Number
- 11
- Start Page
- 977
- End Page
- 983
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14124
- DOI
- 10.1089/jmf.2012.2739
- ISSN
- 1096-620X
- Abstract
- In this study, the protective effect of sweet potato extract against hydrogen peroxide-induced oxidative stress and cytotoxicity on the pheochromocytoma cell line (PC12) was investigated. The active component of the sweet potato extract was purified and determined to be 2,4-di-tert-butylphenol. The antioxidant capacity of 2,4-di-tert-butylphenol was measured by using 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) radical. To examine the effects of 2,4-di-tert-butylphenol on amyloid-beta peptide (A(1-42))-induced learning and memory impairment in mice, in vivo behavioral tests were performed. Administration of 2,4-di-tert-butylphenol increased alternation behavior in mice injected with A(1-42). These results suggest that sweet potato extract could be protective against A-induced neurotoxicity, possibly due to the antioxidative capacity of its constituent, 2,4-di-tert-butylphenol.
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