Outcomes of ovarian preservation in a cohort of premenopausal women with early-stage endometrial cancer: A Korean Gynecologic Oncology Group study
- Authors
- Lee, Taek Sang; Lee, Jung-Yun; Kim, Jae-Weon; Oh, Sohee; Seong, Seok Ju; Lee, Jong Min; Kim, Tae Jin; Cho, Chi Heum; Kim, Seok-Mo; Park, Chan-Yong
- Issue Date
- Nov-2013
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Endometrial cancer; Ovarian preservation; Premenopausal women
- Citation
- GYNECOLOGIC ONCOLOGY, v.131, no.2, pp.289 - 293
- Journal Title
- GYNECOLOGIC ONCOLOGY
- Volume
- 131
- Number
- 2
- Start Page
- 289
- End Page
- 293
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14142
- DOI
- 10.1016/j.ygyno.2013.08.024
- ISSN
- 0090-8258
- Abstract
- Objective. The aim of this study was to evaluate the impact of ovarian preservation on the recurrence and survival rates of premenopausal women with early-stage endometrial cancer. Methods. Using medical records of premenopausal women who received primary surgical treatment for stage I-II endometrial cancer, the demographics and survival rates were compared retrospectively for patients who had ovarian preservation and those who underwent bilateral salpingo-oophorectomy. Cox proportional hazards models with inverse probability of treatment weighting (IPTW) based on propensity score were performed to adjust for selection bias between the two groups. Results. A total of 495 women were identified, including 176 patients who had ovarian preservation. The ovarian preservation group was younger (P < 0.001) and had an earlier year of diagnosis (P = 0.014), a lower prevalence of lymphadenectomy (P < 0.001), and a marginally significant association with lower tumor grade (P = 0.052). The Kaplan-Meier curve and the log rank test showed no difference in either recurrence-free survival (P = 0.742) or overall survival (P = 0.462) between the two groups. In a multivariate Cox model adjusted by IPTW and covariates, ovarian preservation had no effect on either recurrence (hazard ratio [HR], 0.73; 95% CI, 0.29-1.81) or overall survival (HR, 1.33; 95% CI, 0.43-4.09). Conclusions. Ovarian preservation does not appear to be associated with an adverse impact on the outcomes of premenopausal women with early-stage endometrial cancer. The present study has useful implications for physicians counseling young women who want to preserve their ovaries. (C) 2013 Elsevier Inc. All rights reserved.
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